Research Scientist/Engineer 3

Job Description

Research Scientist/Engineer 3

Req #: 235660 Department: BIOENGINEERING Job Location: Seattle Campus Posting Date: 06/17/2024 Closing Info: Closes On 06/24/2024 Salary: $5,427 - $6,800 per month Other Compensation: Union Position: Yes Limited Recruitment: Other
Shift: First Shift Benefits: As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here. As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem-solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty.
UW Bioengineering is a vibrant community driving advances in health care. As a joint department in the College of Engineering and School of Medicine, we bring together students, scientists, engineers, and clinicians to develop innovative and cost-effective health care solutions that improve lives. Our inclusive and collaborative culture empowers our students, faculty, and staff to make an impact through new fields of research and clinical products. Our award-winning faculty are national leaders in biomedical education, research, and technology transfer.
In UW Bioengineering, we are bound by a belief that public health and human dignity are inseparable. One is impossible without the other. Equity and inclusivity are fundamental to our mission of inventing the future of medicine.
POSITION PURPOSE
The position supports ongoing research in the Folch lab in the Department of Bioengineering at the University of Washington. Our lab is developing integrated aptamer-based sensors to detect the release of cytokines from large arrays of microdissected tumor “cuboids”. Unlike organoids, our cuboids feature an intact tumor microenvironment and thus promise to become efficient predictors of human disease outcomes. Since most drug evaluations increasingly require the testing of combination therapies including immunotherapies, the measurement of cytokine release as an assay of immune cell function has become of central importance. This position will expand ongoing efforts on the development of aptamer-based cytokine sensors, with an emphasis on increasing the throughput (more samples), multiplexing (more cytokines), and sensitivity of the existing sensors, preferably with electrochemical methods.
DUTIES AND RESPONSIBILITIES
Research activities (75%)

Create, improve, and/or optimize new aptamer systems for known cytokines and the cell-death indicator cytochrome C.

Improve the sensitivity and throughput of the electrochemistry recording setup.

Write program codes for electrochemical data processing.

Operate the electrochemical station.

Microfabricate (e.g. by laser cutting, 3D printing, molding, etc.) new electrochemistry electrodes on various substrates.

Learn to generate and excise tumors.

Participate in mouse procedures as an assistant and undergo training to be primary surgeon.

Manage and maintain a small animal colony.

Manage IACUC protocols for all animal models, including annual and triennial reviews as well as leading site visits, and ensure experiments adhere to university animal use guidelines.

Assist internal and external collaborators with project design, data collection, and downward analysis, especially pertaining to small animal studies.

Perform endpoint collection such as tissue collection and IVIS/confocal imaging.

Perform lab bench work including, but not limited to, ELISA, flow cytometry, qPCR, RNA extractions.

Research reporting, Grant writing, and laboratory support (25%)

Analyze and present data for collaborators, subgroup, and lab meetings.

Train undergraduates and other lab members in basic lab procedures.

Oversees the work of undergraduate and/or graduate students in the lab.

Trains lab members on the safe and proper use of equipment. Follow up to correct misuse of equipment.

Report problems to the PI or lab manager.

Follows standard operating protocols and perform assigned tasks in a manner that is safe for self and others in the lab.

MINIMUM REQUIREMENTS

Bachelor’s degree in a related field such as chemistry or biochemistry and at least four years of relevant experience in electrochemistry and aptamer-based studies ,

OR

Equivalent combination of education/experience.

ADDITIONAL REQUIREMENTS

Experience in real-time monitoring of chemical molecules in vitro and in vivo

Experience managing IACUC protocols for animal models

Experience in electrochemical-aptamer based biosensor design and optimization
DESIRED QUALIFICATIONS

MS or doctoral degree in chemistry, bioengineering or related field.

Experience in the pharmaceutical field.

Experience in electrochemical-aptamer based biosensor design and optimization.

Experience in real-time monitoring of chemical molecules in vitro and in vivo.

Experience managing IACUC protocols for animal models.

Highly organized with a strong attention to detail.

Self-motivated with the ability to take initiative and work independently.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.

The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.

To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or [email protected] .

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law .

Apply for this job