Principal Scientist, Target Validation Sciences (Oncology), Research

Job Description

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Job Description

”Better Health for People, Brighter Future for the World” is the purpose of a company. We aim to create a diverse and inclusive organization where people can thrive, grow and realize their own potential while enabling our purpose. We continue to innovate and drive changes that will transform the lives of patients. We’re looking for like-minded professionals to join us.

Takeda is a global values-based, R&D-driven biopharmaceutical leader. We are guided by our values of Takeda-ism, which has been passed down since the company’s founding. Takeda-ism incorporates Integrity, Fairness, Honesty, and Perseverance, with Integrity at the core. They are brought to life through actions based on Patient-Trust-Reputation-Business, in this order.

The purpose of the Target Validation Sciences (TVS) is to drive pipeline value creation and acceleration by collaborating closely with Drug Discovery Units (DDUs) and other platform functions. It focuses on validating innovative drug targets using cutting-edge biological platforms that reflect relevant human biology.

• Primarily drive early drug discovery projects by designing and conducting experiments, developing complex assays, and providing strategic input to advance innovation in oncology research.
• Lead lab-related activities, mentor junior scientists, and establish strong relationships with internal and external partners to achieve project goals and enhance productivity.
• Stay at the forefront of scientific advancements, generate new ideas, and contribute to decision-making processes to support the discovery of novel therapies and expand the global Takeda Oncology pipeline.
• Integrate advanced technologies, deliver comprehensive reports, and actively contribute to the growth and development of the team and organization.

ACCOUNTABILITIES

• Play a central role in designing and conducting critical experiments for target validation for oncology, cross-functionally working with Oncology DDU and other teams across Japan and US
• Independently develop and validate relevant complex assays for drug discovery and target validation with minimal supervision
• Contribute to strategic input and participate in decision-making processes in drug discovery projects, identifying opportunities to advance global Takeda Oncology pipeline
• Constantly propose new ideas to drive projects forward, ensuring high scientific standards and innovation
• Maintain a high level of expertise by staying updated on current scientific advancements and emerging technologies
• Build and maintain productive relationships with internal and external partners, enhancing collaboration and scientific impact
• Prepare and present written reports of work to communicate findings and progress effectively
• Mentor and develop junior staff members, fostering an environment of growth and scientific excellence
• May participate in the evaluation of external collaboration opportunities

REQUIREMENTS:

• Ph.D. or M.Sc. in a relevant scientific field such as cell biology, molecular biology, pharmacology, biochemistry, or a related discipline. Expertise in neuroscience is required.
• Expertise in oncology and cancer biology.
• Experience in gene modification experiments, including cell culture, viral transaction, and in vitro/in vivo modelling.
• Experience in single-cell and spatial multi-omics is preferred.
• Critical thinking and problem-solving skills.
• Understanding of data management and analysis.
• Effective work in an interdisciplinary and collaborative environment.
• Communication skills in both English and Japanese, organizational skills, and team collaboration.
• Familiarity with bioinformatics and proficient use of scientific databases is a plus.

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Better Health, Brighter Future

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.
• Salary Increase: Annually, Bonus Payment: Twice a year
• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45
• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.
• Flexible Work Styles: Flextime, Telework
• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company’s discretion.
• It is possible the department and workplace may change at the company’s discretion.

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