Senior Scientist, BioScience, In-vitro Discovery

Job Description

Senior Scientist, BioScience, In-vitro Discovery

Are you driven by the desire to discover and deliver life-changing medicines? Do you have expertise in Biologics Engineering and want to make a significant impact in a company that transforms scientific ideas into reality? AstraZeneca is looking for a passionate individual to join our team and contribute to the development of groundbreaking medicines!

Accountabilities

As a Senior Scientist, you will play a pivotal role in advancing our biologics pipeline. You will independently design and execute discovery campaigns using phage and yeast-display technologies. Your responsibilities will include recovering yeast plasmids, preparing samples for NGS data generation, analyzing NGS data with software like Geneious Biologics, and selecting hit lists for antibody production. You will contribute to technology platform builds, streamline discovery workflows, and present data as a lead scientist in multidisciplinary project teams. Collaboration across multiple groups in a matrixed environment is essential.

Essential Skills/Experience

• A PhD, or equivalent experience, in Molecular Biology, Biochemistry, Immunology, with 0-6 years of post-doctoral experience in a relevant research area, a Master’s degree in a related field with 2+ years of relevant laboratory experience, or a Bachelor’s degree in Molecular Biology, Biochemistry, Immunology or related disciplines with 5+ years of laboratory experience. Industry experience is a plus but not required.
• Extensive and current hands-on experience with phage and yeast-display technology for antibody discovery.
• Proven hands-on experience with NGS data generation (sample prepping) and sequence analysis.
• Data science and/or coding (python) skills highly desirable.
• Experience in high-throughput cloning, DNA sequence analysis, protein expression and purification, ELISA, flow cytometry, and tissue culture.
• Ability to work independently and in a team setting.
• Self-motivated, diligent, and flexible in accommodating shifting priorities.
• Strong communication and interpersonal skills, both oral and written, with supervisor, team, and various cross-functional project team members.
• Maintain accurate and well-organized laboratory records, including worksheets, lab notebooks, inventories, and databases.

Desirable Skills/Experience

• Experience working with various antibody formats including VHH, scFv and Fab.
• Familiarity with handling large datasets; data science skills are a plus.
• Transfection/electroporation, culturing and expansion of mammalian cells.
• Experience with ELISA, MSD, cytotox and biolayer interferometry binding assays highly desirable.
• Experience with electronic notebook keeping and data entry using Gene Data Biologics.

AstraZeneca offers an empowering environment where you can act swiftly on smart risks. Our dynamic approach keeps us ahead in the fast-paced Oncology field. We encourage fearless decision-making and constructive challenges while always following scientific evidence. With one of the broadest Oncology pipelines in the industry, you'll have the opportunity to work with novel drugs and make bold moves that transform cancer treatment.

Apply now to join our team at AstraZeneca!

The annual base pay for this position ranges from $ 108,473.60 - 162,710.40. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.