Medical Affairs Lead - (MAL) CVRM - Hyperkalaemia and Metabolic

Job Description

Medical Affairs Lead (MAL) CVRM - Hyperkalaemia and Metabolic

London

Competitive Salary & Benefits

Advert Closing Date: 21st July 2025

AstraZeneca is at the forefront of science-led innovation in Cardiovascular, Renal, and Metabolic (CVRM) diseases. As we expand our focus into obesity and liver disease, we are investing in an industry leading portfolio that will reshape how these conditions are managed, and we’re looking for a Medical Affairs Lead (MAL) to play a pivotal role in that transformation.

This is a unique opportunity to join our team at a critical moment of innovation and impact. You’ll lead medical strategy across early metabolic assets, particularly in weight management and liver disease and our inline asset in hyperkalaemia, building strong cross-functional collaborations and external partnerships that can genuinely change lives.

• Drive the pre-launch and launch strategy for AstraZeneca’s next-generation obesity and liver disease portfolio, preparing the UK business for future success.
• Lead the UK medical strategy for Hyperkalaemia, with oversight of Lokelma, while mentoring and supporting the Hyperkalaemia Medical Affairs Manager (MAM).
• Map the current UK landscape, including clinical pathways, expert networks, and evidence gaps in obesity and liver cirrhosis management.
• Shape future standards of care by seeing opportunities for pathway transformation and tangible clinical impact.
• Build and maintain deep external relationships with key external experts (KEEs), academic leaders, professional societies, payers, and patient advocacy groups.
• Co-create and deliver education, engagement, and evidence-generation initiatives to support launch excellence.
• Provide medical leadership to the field team (MSLs), guiding field strategy and execution to align with launch priorities and medical KPIs.
• Represent the UK in Global and European Medical Affairs forums, bringing local insight and strategy to global planning.
• Ensure alignment with compliance, ethical standards, and the UK (QMS) SOPs.

Essential Skills/Experience

• Registered Physician (preferably GMC) or Pharmacist (General Pharmaceutical Council)
• Strong experience in Medical Affairs, ideally in a leadership capacity within the metabolic, cardiovascular or obesity space
• Expertise or interest in obesity and liver disease including knowledge of the current landscape, treatment options, and emerging science.
• Proven track record of developing and implementing strategy, ideally including launch preparation and cross-functional leadership.
• Excellent communication and external engagement skills – able to build credibility with top-tier clinicians, payers, and advocacy leaders.
• A strategic thinker with a clear sense of purpose, clinical insight, and customer-centricity.

Desirable Skills/Experience

• Member/Fellow of a Royal College or the Royal Pharmaceutical Society
• Launch experience in CVRM and/or specialist care and/or acute care medicines
• Detailed knowledge of the UK healthcare system
• Proven expertise in the ABPI Code of Practice
• Extensive patient and customer insight through experience of working with the NHS
• It is highly desirable for the candidate to hold or successfully acquire Nominated Signatory status. You will be required to gain Nominated Signatory status within 6 months of commencing your role. You are also required to pass re-validation testing every 12 months or as requested.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

AstraZeneca offers an environment where you can be at the forefront of medical innovation. We use our unique position as medical leaders across our enterprise and the healthcare ecosystem to shape the future of healthcare. Here, you can improve patients' lives while developing your career. Our collaborative culture fosters innovation and allows us to make a meaningful impact on patients' lives.

At AstraZeneca UK, we are committed to delivering against three missions:

• Accelerating the position of the UK as a global centre of excellence in life sciences
• Redefining healthcare through fast and equitable access to the most effective medicines, high quality care
• Delivering sustainable leadership that prioritises healthy people, society and planet

Our head office in Pancras Square offers us the strongest possible platform to transform the lives of patients, as the country’s leading biopharmaceutical company. It brings AstraZeneca UK closer to our customers, partners and collaborators in the UK’s healthcare environment, as well as develop greater collaboration with the wider AstraZeneca footprint.

Ready to make a difference? Apply now!

Date Posted

14-Jul-2025

Closing Date

21-Jul-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.